Pituitary hypothyroidism is a rare condition characterized by low levels of thyroid hormone due to failure of the pituitary gland. The pituitary gland is a pea-sized structure in the brain that releases thyroid-stimulating hormone (TSH). This hormone circulates in the blood and tells the thyroid to release its own hormones. Show
Low thyroid levels can be due to failure of the thyroid gland itself (primary hypothyroidism) or failure of the pituitary gland (secondary hypothyroidism). Pituitary failure can manifest with several potential symptoms. Read on to learn more about the symptoms, diagnosis, and treatment of secondary hypothyroidism. kitzcorner / Getty Images Secondary Hypothyroidism SymptomsThyroid hormones are involved in many metabolic processes throughout the body. Symptoms of hypothyroidism generally include the following:
The symptoms listed above are common to primary and secondary hypothyroidism. Some additional symptoms are due to specific causes of pituitary failure (such as brain tumor) or due to low levels of other hormones. These symptoms can include:
Undiagnosed HypothyroidismAt its most severe, undiagnosed hypothyroidism can manifest as myxedema. This life-threatening condition is characterized by swelling, slowed heart rate, low blood pressure, confusion, low body temperature, and fluid buildup around the heart. It requires hospitalization for urgent treatment. What Causes Secondary Hypothyroidism?The body functions best when hormone levels are maintained in the correct range. To accomplish this, the brain and endocrine organs work together through complex feedback loops. The process starts in the part of the brain called the hypothalamus. The hypothalamus releases a hormone called thyrotropin-releasing hormone (TRH). This hormone signals the pituitary gland to release thyrotropin, also known as thyroid-stimulating hormone (TSH). TSH then signals the thyroid gland to release its own hormones, triiodothyronine and thyroxine (called T3 and T4 for short). T3 and T4 circulate in the blood and affect many biological processes, resulting in symptoms when levels are either too high or too low. The T3 and T4 then interact with the hypothalamus, telling it to secrete more or less thyrotropin-releasing hormone. When any parts of the feedback loop are not functioning appropriately, thyroid levels can become either too high or too low, resulting in various symptoms. For example, pituitary failure results in inadequate TSH release, and subsequently low thyroid hormone (T3 and T4) levels. Pituitary failure may be caused by:
Hormones Involved in Thyroid RegulationThe hormones involved in thyroid regulation include:
How Is Secondary Hypothyroidism Diagnosed?Hypothyroidism is generally diagnosed with blood tests. Measuring low thyroid levels and circulating hormones can help determine where the problem is. A low T3 and T4 and inappropriately low or normal TSH localizes the problem to the brain, either the pituitary gland or hypothalamus. Brain imaging is performed using magnetic resonance imaging (MRI) to evaluate for underlying causes and to rule out other possibilities. When secondary hypothyroidism is diagnosed, evaluating other hormone systems, like cortisol, growth hormone, and sex hormones, is necessary, Classification of HypothyroidismHypothyroidism can be classified according to which part of the feedback loop is affected, such as:
Is Secondary Hypothyroidism Treatable?Fortunately, hypothyroidism is treatable with medication. Thyroid hormones can be replaced with a synthetic thyroid hormone called levothyroxine. Alternatively, desiccated thyroid hormone derived from thyroid glands of animals (known as Armour thyroid) can be administered. In secondary hypothyroidism, hormone levels are monitored to ensure appropriate dosing of thyroid hormone. The underlying cause of secondary hypothyroidism also needs to be addressed. Pituitary tumors, one of the more common causes of secondary hypothyroidism, may require surgery. Outlook for Secondary HypothyroidismWhile the management of hypothyroidism is straightforward and achievable with medication, the overall prognosis of secondary hypothyroidism is variable, depending on the underlying cause. Conditions like cancer, infection, head trauma, or bleeding need to be addressed to truly understand the overall prognosis. SummarySecondary hypothyroidism, also known as pituitary hypothyroidism, is a condition in which failure of the pituitary gland results in low thyroid stimulating hormone (TSH) and, subsequently, low thyroid hormone levels. Symptoms include fatigue, weight gain, constipation, menstrual irregularities, and skin, hair, and nail changes. Diagnosing secondary hypothyroidism involves laboratory blood testing, and brain imaging is required to evaluate any underlying causes of pituitary failure. Hypothyroidism is treatable with medication, including synthetic thyroid hormones. The overall prognosis depends on the underlying cause. A Word From VerywellBecause pituitary hypothyroidism is not common, achieving a diagnosis can be a stressful and complex experience. Know that low thyroid hormone disorders are treatable, though it can take time to start feeling better. Work with your healthcare provider to determine the appropriate dose of thyroid replacement medication so you can feel better sooner. Frequently Asked Questions
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Angela Ryan Lee, MD Thanks for your feedback! Are TSH levels high in secondary hypothyroidism?Total T3. Serum TSH -- Results are generally low in secondary hypothyroidism because the pituitary is damaged. However, normal or even high values may be seen.
What levels of TSH indicate hypothyroidism?Ultimately, the standard of care is to treat into the goal range for TSH, which is typically between 0.5 and 4.5 or 5. A TSH level of 10 mIU/L or higher is typically indicative of hypothyroidism. A TSH level of 4.5 to 10 mIU/L is considered indicative of subclinical hypothyroidism.
Why is TSH high in secondary hyperthyroidism?Secondary hyperthyroidism may be attributed to an over-stimulation of the thyroid. This may be due to increased production of TSH from the pituitary gland or TSH-secreting tumor, or more rarely from overproduction of TRH from the hypothalamus or thyrotropin-releasing hormone (TRH)-secreting tumor.
What is the difference between primary hypothyroidism and secondary hypothyroidism?Primary hypothyroidism occurs after destruction of the thyroid gland because of autoimmunity (the most common cause), or medical intervention such as surgery, radioiodine, and radiation. Secondary hypothyroidism occurs after pituitary or hypothalamic damage, and results in insufficient production of TSH.
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