What is the difference between igg and igm herpes test

Ordering Recommendation

Recommendations when to order or not order the test. May include related or preferred tests.

Table of Contents Show

Ordering Recommendation
Methodology
New York DOH Approval Status
Specimen Required
Reference Interval
Interpretive Data
Do IgG herpes levels mean anything?
How long does HSV IgG stay positive?
Are HSV IgM tests accurate?
What does a negative IgM herpes test mean?

Not recommended for herpes simplex virus (HSV) testing; lacks adequate predictive value for acute infection. Preferred testing is Herpes Simplex Virus (HSV-1/HSV-2) Subtype by PCR (2010095).

Mnemonic

Unique test identifier.

HERPRCSF

Methodology

Process(es) used to perform the test.

Semi-Quantitative Chemiluminescent Immunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Days of the week the test is performed.

Sun-Sat

Reported

Expected turnaround time for a result, beginning when ARUP has received the specimen.

1-2 days

New York DOH Approval Status

Indicates test has been approved by the New York State Department of Health.

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Specimen Preparation

Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Specimen types other than CSF. Contaminated, heat-inactivated, or hemolyzed specimens.

Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Normal range/expected value(s) for a specific disease state. May also include abnormal ranges.

Test Number	Components	Reference Interval
	HSV 1 and/or 2 Antibodies IgM, CSF	0.89 IV or less
	HSV 1/2 Antibody Screen IgG, CSF	0.89 IV or less

Interpretive Data

Background information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Component

Interpretation

Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM, CSF by ELISA

0.89 IV or less; Negative - No significant level of detectable HSV IgM antibody.
0.90-1.09 IV; Equivocal - Questionable presence of IgM antibodies. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater; Positive - IgM antibody to HSV detected which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF

0.89 IV or less: Negative - No significant level of detectable HSV IgG antibody.
0.90-1.09 IV: Equivocal - Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - IgG antibody to HSV detected which may indicate a current or past HSV infection.

Compliance Category

Laboratory Developed Test (LDT)

Note

Additional information related to the test.

If HSV 1/2 IgG, CSF is greater than or equal to 1.10 IV , then HSV 1 gG-Specific IgG, CSF and HSV 2 gG-Specific IgG, CSF will be added. Additional charges apply.

CPT Codes

The American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually.
CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ.
CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.

86694 x2; if reflexed, add 86695; 86696

Components

Components of test

Component Test Code*	Component Chart Name	LOINC
0050394	HSV 1/2 Antibody Screen IgG, CSF	13249-8
0050408	HSV 1 and/or 2 Antibodies IgM, CSF	63432-9

* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Other names that describe the test. Synonyms.

glycoprotein type-specific reactivity
Herpes Simplex Antibodies, IgG IgM CSF
Herpes Simplex CSF
HSV 1, 2 IgG IgM CSF
HSV 1,2
HSV 1,2 and glycoprotein reflex
HSV 1,2 glycoprotein CSF
HSV CSF antibody
HSV glycoprotein G CSF
HSV glycoprotein G-based type-specific CSF

Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG & IgM (CSF) with Reflex to Type 1 & 2 Glycoprotein G-Specific Ab, IgG

Do IgG herpes levels mean anything?

An HSV test with a positive (abnormal) IgG result means that you either have or have had an HSV infection at some point. Since a positive result means that your body has built an IgG immune response to HSV, a negative IgG test means that your body has never needed to do so and you have never been infected with HSV.

How long does HSV IgG stay positive?

The time required for the development of IgG antibodies following HSV infection varies from 21 to over 42 days with most individuals having detectable IgG 21–28 days after exposure to the infection and probably lasting for life.⁷^–,⁹ IgM antibodies are usually detectable 9–10 days after exposure and last 7–14 days, ...

Are HSV IgM tests accurate?

Therefore, IgM tests can lead to deceptive test results, as well as false assumptions about how and when a person actually acquired HSV. For this reason, we do not recommend using blood tests as a way to determine how long a person has had herpes.

What does a negative IgM herpes test mean?

A negative (normal) test most often means you have not been infected with HSV-1 or HSV-2. If the infection occurred very recently (within a few weeks to 3 months), the test may be negative, but you may still be infected. This is called a false negative.