Trimethoprim is a synthetic antibacterial drug active against a wide variety of aerobic gram-positive and Show
gram-negative ophthalmic pathogens. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. This binding is stronger for the bacterial enzyme than for the corresponding mammalian enzyme, and therefore, selectively interferes with bacterial biosynthesis of nucleic acids and proteins. Polymyxin B, a cyclic lipopeptide antibiotic, is bactericidal for a variety of gram-negative organisms, especially Pseudomonas aeruginosa. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane. Blood samples were obtained from 11 human volunteers at 20 minutes, 1 hour and 3 hours following instillation in the eye of 2 drops of ophthalmic solution containing 1 mg trimethoprim and 10,000 units polymyxin B per mL. Peak serum concentrations were approximately 0.03 mcg/mL trimethoprim and 1 unit/mL polymyxin B. MicrobiologyIn vitro studies have demonstrated that the anti-infective components of polymyxin B sulfate and trimethoprim ophthalmic solution, USP are active against the following bacterial pathogens that are capable of causing external infections of the eye: Trimethoprim: Staphylococcus aureus and Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus aegyptius, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis (indole-negative), Proteus vulgaris (indole-positive), Enterobacter aerogenes and Serratia marcescens. Polymyxin B: Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes and Haemophilus influenzae.
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Polytrim Side Effects Center What Is Polytrim?Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution) is an antibiotic indicated in the treatment of surface bacterial infections of the eye, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus viridans, Haemophilus influenzae and Pseudomonas aeruginosa. Polytrim is available in generic form. What Are Side Effects of Polytrim?Common side effects of Polytrim include:
Dosage for PolytrimIn mild to moderate infections, instill a dose of one drop of Polytrim in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days. What Drugs, Substances, or Supplements Interact with Polytrim?Polytrim may interact with other drugs. Tell your doctor all medications and supplements you use. Polytrim During Pregnancy or BreastfeedingTell your doctor if you are pregnant or plan to become pregnant before using Polytrim; it is unknown how it would affect a fetus. It is unknown if Polytrim passes into breast milk. Consult your doctor before breastfeeding. Additional InformationOur Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. SLIDESHOWPink Eye (Conjunctivitis) Symptoms, Causes, Treatments See SlideshowPolytrim Consumer Information 3 pharmacies near 98837 have coupons for Polytrim (Brand Names:Polytrim for 10ML of 10000-0.1UNIT/ML-%)Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have:
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Read the entire detailed patient monograph for Polytrim (Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution, USP, Sterile) QUESTIONWhat causes dry eyes? See AnswerPolytrim Professional Information SIDE EFFECTSThe most frequent adverse reaction to POLYTRIM® Ophthalmic Solution is local irritation consisting of increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use. There are also multiple reports of hypersensitivity reactions consisting of lid edema, itching, increased redness, tearing, and/or circumocular rash. Photosensitivity has been reported in patients taking oral trimethoprim. Read the entire FDA prescribing information for Polytrim (Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution, USP, Sterile) © Polytrim Patient Information is supplied by Cerner Multum, Inc. and Polytrim Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. Health Solutions From Our Sponsors
Can you use polymyxin B sulfate and trimethoprim for pink eye?Polymyxin B and trimethoprim ophthalmic combination is used to treat bacterial infections of the eye including conjunctivitis (pinkeye; infection of the membrane that covers the outside of the eyeball and the inside of the eyelid) or blepharoconjunctivitis (infection of the membrane that covers the outside of the ...
How long does polymyxin take to work for pink eye?Pink eye caused by bacteria will take about 24–48 hours before symptoms improve once a person is on antibiotics. Pink eye caused by a virus takes anywhere from a few days to more than a week to resolve.
Can you use polymyxin B sulfate and trimethoprim ophthalmic solution for eyes?Polymyxin B and trimethoprim combination is used to treat eye infections, including acute bacterial conjunctivitis and blepharoconjunctivitis. Polymyxin B and trimethoprim belong to the class of medicines known as antibiotics.
How long does it take for pinkeye to clear up?Most cases of viral conjunctivitis are mild. The infection will usually clear up in 7 to 14 days without treatment and without any long-term consequences. However, in some cases, viral conjunctivitis can take 2 to 3 weeks or more to clear up.
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Polymyxin b sulfate and trimethoprim ophthalmic solution for pink eye
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