Published: 17 June 2015 Show
Safety InformationTrans-Tasman Early Warning System - Alert CommunicationIbuprofen and Cardiovascular SafetyInformation for consumers and caregivers Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of acute and/or chronic pain and inflammation. Medsafe and the Medicines Adverse Reactions Committee (MARC) have concluded that there is a small increased risk of cardiovascular thrombotic events with ibuprofen, when used at high doses (2400 mg per day) and in long-term treatment. Overall, the studies suggest that lower doses of ibuprofen (1200 mg per day or less), the dose generally used for over-the-counter (OTC) preparations, are not associated with this increased cardiovascular risk. Information for consumers and caregivers
Information for healthcare professionals
Review SummaryThe Medicines Adverse Reactions Committee (MARC) reviewed the latest data on the association of adverse cardiovascular events in patients taking ibuprofen in March 2015. The MARC concluded that there was a small increase in the risk of cardiovascular events with the use of high dose ibuprofen (2400 mg per day). The MARC noted that the published studies were observational, underpowered and confounded. Therefore, the conclusions that could be reached were limited. There was a hint of a dose-response effect suggesting that there was no increased risk of myocardial infarction in doses less than or equal to 1200 mg daily. Available data on this risk with doses between 1200 mg and 2400 mg daily was insufficient to draw firm conclusions. There was evidence that there was an increased risk at a dose of 2400 mg daily. Examples of data reviewed are shown below:
 Figure 1: Pooled and individual relative risks and 95% confidence intervals for the risk of myocardial infarction associated with the use of naproxen, ibuprofen and diclofenac compared with no NSAID use1 Figure 2: Effects of ibuprofen (2400 mg daily) on major vascular events, heart failure, cause-specific mortality and upper gastrointestinal complications2 Table 1: Hazard ratios for death and rehospitalisation for myocardial infarction (Cox proportional hazards analysis)3 References
What actions are Medsafe taking?Medsafe is working with the sponsors of these products to ensure data sheets and Consumer Medicine Information appropriately outline the safety of ibuprofen. No changes are being requested to over-the-counter (OTC) preparations. How to report adverse events
Further informationEuropean Medicines Agency decision What happens if you take ibuprofen with high blood pressure?Ibuprofen (Advil, Motrin) can raise your blood pressure. But this change is usually small. If you have high blood pressure or heart problems, make sure to check with your healthcare provider before taking ibuprofen. Using ibuprofen regularly can cause potentially serious side effects, such as stomach ulcers.
What kind of pain reliever can I take with high blood pressure?Acetaminophen (Tylenol) is often the pain reliever of choice for people with high blood pressure (hypertension) because most other options are types of nonsteroidal anti-inflammatory drugs like ibuprofen (Motrin, Advil) or naproxen (Naprosyn, Aleve), which can raise blood pressure.
Can people with blood pressure take ibuprofen?Unless your doctor has told you it's OK, do not use over-the-counter ibuprofen, naproxen sodium, or ketoprofen for pain relief. Instead, use a painkiller less likely to increase your blood pressure, like aspirin or acetaminophen.
Can you take Tylenol or ibuprofen with high blood pressure?But it turns out, they come with plenty of risks — especially for people with high blood pressure. The American Heart Association (AHA) has long recommended acetaminophen (Tylenol) as a safe alternative to nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve).
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Is ibuprofen okay to take with high blood pressure
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